APPLICATION OF THE JELLYFISH MODEL .1. VIRULENCY OF SOME MAMMALIAN VIRUSES

In contrast to natural sequence of trypsin, functional sites of polar sequence of trypsin can be predicted only in the presence of cleavage site (CL) of the substrate, surface protein-F of viruses having strong or intermediate virulencies (Jellyfish model). In the case of less-vi rulent viruses, however, things are not so simple as virulent ones and sometimes DEV model fails to predict the functional sites which are a lready assigned empirically by virologists as the cleavage site just u pstream to the long span of hydrophobic amino acids in the natural seq uence. Actually, there are lots of weak virulent viruses in nature. Si mple mathematical calculation supports this possibility which suggests a limitation in the application of our models. Mutation and selection are considered to control these situations (Appendix).