TOTAL SYNTHESIS OF 1-ALPHA,25-DIHYDROXY-18-NORVITAMIN D-3

Authors
SAS B DECLERCQ P VANDEWALLE M
Citation
B. Sas et al., TOTAL SYNTHESIS OF 1-ALPHA,25-DIHYDROXY-18-NORVITAMIN D-3, Synlett, (10), 1997, pp. 1167
Citations number
27
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
10
Year of publication
1997
Database
ISI
SICI code
0936-5214(1997):10<1167:TSO1D>2.0.ZU;2-4
Abstract
1 alpha,25-Dihydroxy-18-norvitamin D-3 2a has been synthesized via two routes. In the first one, the CD-ring fragment 3 was obtained by an i ntermolecular Diels-Alder reaction via a decalin intermediate and subs equent ring contraction. The second approach is based on an intramolec ular Diels-Alder reaction of a preconstructed nonatriene 8.