SYNTHESIS AND BIODISTRIBUTION OF NEW OXO AND NITRIDO TE-99M COMPLEXESWITH ASYMMETRICAL POTENTIALLY DIANIONIC OR TRIANIONIC TETRADENTATE SNNO LIGANDS DERIVED FROM METHYL-2-AMINOCYCLOPENTENE-1-DITHIOCARBOXYLIC ACID

In this work, 10 new asymmetrical tetradentate SNNO ligands were prepa red by reaction of the amine function of methyl -aminoethyl)amino]cycl opentene-1-dithiocarboxylate with various bifunctional substituents be aring hydroxyl/ketone and hydroxyl/aldehyde functional groups and with diethyl oxalate. Tc-99m labeling efficiency was optimized by adjustin g temperature and pH conditions. Seven nitrido and two oxo (TC)-T-99m complexes were isolated. Six of them proved to be stable near physiolo gical conditions. Biodistribution studies in the rat showed a signific ant heart uptake for four of them and strong kidney and liver uptake f or the other two. (C) 1998 Elsevier Science Inc.