The poor prognosis of amyotrophic lateral sclerosis (ALS) makes pallia
tive care a challenge for the neurologist. Most disabilities associate
d with progressive disease can be ameliorated by symptomatic treatment
. Prognosis and treatment options should be openly discussed with the
patient and his/her relatives. Nutritional deficiency due to pronounce
d dysphagia can be efficiently relieved by a percutaneous enterogastro
stomy. Respiratory insufficiency can be treated by non-invasive ventil
ation at home, provided the familial environment is supportive. Adequa
te assistance and palliative treatment in the terminal phase is of par
amount importance.