RELATIONSHIPS BETWEEN CHANGES IN SYMPTOM RATINGS, NEUROPSYCHOLOGICAL TEST-PERFORMANCE AND QUALITY-OF-LIFE IN SCHIZOPHRENIC-PATIENTS TREATEDWITH CLOZAPINE

This study examined the correlations between reduction in symptoms, ch anges in neuropsychological test performance and improved quality of l ife in 19 schizophrenic outpatients treated with clozapine. Reduction in both negative symptoms and general psychopathology was associated w ith a better quality of life. Some improvement in neuropsychological t est performance was found, with a variable pattern of association with change in psychopathology. Improved verbal fluency was associated wit h reduction in negative symptoms, while improved verbal concept format ion was associated with reduction in positive symptoms. (C) 1997 Elsev ier Science Ireland Ltd.