A case is described where phototherapy rapidly restored sleep-wake dis
turbances and concurrent symptoms of delirium in a patient who did not
respond to conventional treatment with haloperidol. In this case, the
delirious state may have been caused by a change in metabolism as a r
esult of sepsis. Exposition of the patient to 8,000 Lux during 1.5 h f
or 5 consecutive days was sufficient to suppress all delirious symptom
s and to normalize sleep. This result may encourage the setup of syste
matic studies towards the extent of desynchronization between various
rhythmic cycles in delirium and towards the value of phototherapy for
the restoration of normal circadian rhythmicity.