PROTECTIVE EFFECTS OF GRANULOCYTE-COLONY-STIMULATING FACTOR ON ENDOTOXIN-SHOCK IN MICE WITH RETROVIRUS-INDUCED IMMUNODEFICIENCY SYNDROME

Authors
TOKI S HIROMATSU K AOKI Y MAKINO M YOSHIKAI Y
Citation
S. Toki et al., PROTECTIVE EFFECTS OF GRANULOCYTE-COLONY-STIMULATING FACTOR ON ENDOTOXIN-SHOCK IN MICE WITH RETROVIRUS-INDUCED IMMUNODEFICIENCY SYNDROME, Cytokine, 9(10), 1997, pp. 781-786
Citations number
35
Categorie Soggetti
Cell Biology",Biology,Immunology
Journal title
Cytokine → ACNP
ISSN journal
10434666
Volume
9
Issue
10
Year of publication
1997
Pages
781 - 786
Database
ISI
SICI code
1043-4666(1997)9:10<781:PEOGFO>2.0.ZU;2-V
Abstract
Mice with retrovirus-induced murine acquired immunodeficiency syndrome (MAIDS) were hypersensitive to lipopolysaccharide (LPS)-induced letha l shock accompanied by marked elevations of systemic interleukin 1 bet a (IL-beta) and interferon gamma (IFN-gamma) after LPS challenge. Pret reatment with 10 mu g of recombinant human granulocyte colony-stimulat ing factor (rhG-CSF) protected MAIDS mice from hypersensitivity to LPS -induced lethal shock and this protection was concomitant with suppres sion of IFN-gamma production. (C) 1997 Academic Press Limited.