KINETICS OF PROTON-TRANSFER FROM BENZOYLNITROMETHANE AND 1,2-DIPHENYL-2-NITROETHANONE TO VARIOUS BASES - RESONANCE, INDUCTIVE, SOLVATION, STERIC, AND TRANSITION-STATE HYDROGEN-BONDING EFFECTS ON INTRINSIC RATECONSTANTS

The replacement of a hydrogen in nitromethane and in phenylnitromethan e by the PhCO group has a strong acidifying effect, i.e., PhCOCH2NO2, 5, is 5.8, 6.6, and 8.6 pK(a) units more acidic than CH3NO2 in water, 50% DMSO-50% water (v/v), and 908 DMSO-10% water (v/v), respectively, and PhCOCH(Ph)NO2, 6, is 2.0, 3.0, and 3.2 pK(a) units more acidic tha n PhCH2NO2 in the same solvents. A major focus of this paper is an att empt to sort out the relative contributions of resonance, inductive/fi eld, and solvation effects that lead to the increased acidities. To th is end rate constants for the reversible deprotonation of 5 by seconda ry alicyclic amines in water, 50% DMSO-50% water (v/v), and 90% DMSO-1 0% water (v/v) and for the reversible deprotonation of 6 by secondary alicyclic amines, carboxylate ions, thiolate ions, and aryloxide ions in water, by secondary alicyclic and primary aliphatic amines in 50% D MSO, and by secondary alicyclic anions in 90% DMSO were determined. Fr om Bronsted plots based on these data the intrinsic rate constants (k( o)) for the reactions of 5 and 6 with the various buffer families were obtained and compared with previously determined k(o) values for the deprotonation of CH3NO2 and PhCH2NO2, respectively. An analysis of the changes in k(o) induced by the introduction of the PhCO group, couple d with a comparison of solvent transfer activity coefficients for the transfer of the anions (5(-) and 6(-)) from water to 50% and 90% DMSO with those for CH2=NO2- and PhCH=NO2-, respectively, indicates a subst antial increase in the resonance stabilization of 5-relative to CH2=NO 2- and a corresponding sharp drop in the solvational stabilization by hydrogen bonding from water; the effects on 6(-) are qualitatively sim ilar but quantitatively much smaller. Our study also shows that the in trinsic rate constant for proton transfer from 6 to thiolate ions is h igher than for proton transfer to aryl oxide ions and amines. This res ult indicates that, in contrast to most other proton-transfer reaction s, hydrogen-bonding stabilization of the transition state for deproton ation of 6 is not an important factor.