Growth hormone prepared by recombinant DNA technology (somatropin) has
been commercially available for over Il years. More than 38000 childr
en have been treated with different growth hormone products. While the
best response to treatment occurs in children with severe growth horm
one deficiency, therapy with growth hormone will increase the rate of
statural growth in children with short stature of many different aetio
logies. There are few studies of the effect of growth hormone treatmen
t on final adult height, and the magnitude of this effect is harder to
gauge, particularly in children with idiopathic short stature. Other
benefits of growth hormone treatment in children include improvement i
n psychosocial functioning and physiological parameters, such as bone
mineral density. Adverse effects associated with growth hormone treatm
ent have been relatively uncommon. Most of the safety data on growth h
ormone have come from large postmarketing databases maintained by 2 ph
armaceutical companies. The adverse event profile reported in children
treated with growth hormone is different from that found in adults. P
eripheral oedema and carpal tunnel syndrome, which are common in adult
s treated with growth hormone and frequently result in treatment disco
ntinuation, are rare in children. Intracranial hypertension is rare, b
ut can occur in children with growth hormone deficiency, Ullrich-Tumer
syndrome or renal insufficiency during the first 8 to 12, weeks after
the start of growth hormone treatment; it has seldom been reported in
adults with growth hormone deficiency. Children with growth hormone d
eficiency, Ullrich-Turner syndrome or renal insufficiency are prone to
develop slipped capital femoral epiphyses both before and during grow
th hormone treatment. Therefore, limping and complaints of hip or knee
pain should be carefully investigated.