We conjecture that M-theory compactified on an ALE space (or K3) is de
scribed by O-branes moving on the ALE space. We give evidence for this
by showing that if we compactify another circle, we recover string th
eory on the ALE space. This guarantees that in the large N limit, the
matrix model correctly describes the force law between gravitons movin
g in an ALE background, We also show the appearance in M(atrix) theory
of the duality of M-theory on K3 with the heterotic string on a three
-torus. (C) 1997 Elsevier Science B.V.