V. Tosato et al., SEQUENCE COMPLETION, IDENTIFICATION AND DEFINITION OF THE FENGYCIN OPERON IN BACILLUS-SUBTILIS-168, Microbiology, 143, 1997, pp. 3443-3450
A 15 kb DNA fragment from the Bacillus subtilis chromosome between cit
B and ppsC has been sequenced, and new ORFs encoding putative enzymes
involved in lipopolypeptide synthesis, which complete a partial operon
previously reported, and a new set of enzymes responsible for lipid m
etabolism have been identified. From the analysis of DNA sequence homo
logy of the fragment it was deduced that these new peptide synthetase
genes are part of an operon for the biosynthesis of the fungicide feng
ycin.