AN EXPEDITIOUS PROCEDURE FOR THE SYNTHESIS OF PURINES FROM AMINOIMIDAZOLECARBALDEHYDES

Reactions of 4-amino-1,2-dimethylimidazole-5-carbalde (1) and 5-amino- 1-methylimidazole-4-carbaldehydes 3 with nitriles, in the presence of dry hydrogen chloride afforded to the formation of purine derivatives. This constitutes a facile and versatile one-pot synthesis of purines. The use of formamide instead of nitriles leads to the respective puri nes without substituents on the pyrimidine ring, 2d and 4e,f.