UNUSUAL NITRATION OF SUBSTITUTED 7-AMINO-1,8-NAPHTHYRIDINE IN THE SYNTHESIS OF COMPOUNDS WITH ANTIPLATELET ACTIVITY

Citation
Pl. Ferrarini et al., UNUSUAL NITRATION OF SUBSTITUTED 7-AMINO-1,8-NAPHTHYRIDINE IN THE SYNTHESIS OF COMPOUNDS WITH ANTIPLATELET ACTIVITY, Journal of heterocyclic chemistry, 34(5), 1997, pp. 1501-1510
Citations number
26
Categorie Soggetti
Chemistry Inorganic & Nuclear
ISSN journal
0022152X
Volume
34
Issue
5
Year of publication
1997
Pages
1501 - 1510
Database
ISI
SICI code
0022-152X(1997)34:5<1501:UNOS7I>2.0.ZU;2-T
Abstract
Several 1,8-naphthyridine derivatives have been diazotizated to obtain the corresponding hydroxy derivatives or mixture of hydroxy and hydro xy nitro derivatives. The respective amounts of hydroxy and hydroxy ni tro derivatives depends on the nature of the substituents, on their po sition on the naphthyridine nucleus, on the amount of sodium nitrite a nd on the reaction temperature. A study of the electronic density of s ome molecules suggests a possible explanation of the effects induced b y the nature of the substituents and of their position. Some of the co mpounds were tested for their ability to inhibit human platelet aggreg ation in vitro induced by arachidonic acid. Only compound 26 showed in teresting antiplatelet activity.