CHEMISTRY OF FUNCTIONALIZED BENZAZEPINES .5. SYNTHESIS AND CHEMICAL TRANSFORMATION OF THE TRAHYDROSPIRO-[3H-2-BENZAZEPINE-3,1'-CYCLOALKANES]

Authors
KOUZNETSOV V PALMA A SALAS S VARGAS LY ZUBKOV F VARLAMOV A MARTINEZ JR
Citation
V. Kouznetsov et al., CHEMISTRY OF FUNCTIONALIZED BENZAZEPINES .5. SYNTHESIS AND CHEMICAL TRANSFORMATION OF THE TRAHYDROSPIRO-[3H-2-BENZAZEPINE-3,1'-CYCLOALKANES], Journal of heterocyclic chemistry, 34(5), 1997, pp. 1591-1595
Citations number
26
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of heterocyclic chemistry → ACNP
ISSN journal
0022152X
Volume
34
Issue
5
Year of publication
1997
Pages
1591 - 1595
Database
ISI
SICI code
0022-152X(1997)34:5<1591:COFB.S>2.0.ZU;2-I
Abstract
The synthesis of new spiro derivatives of tetrahydro-2-benzazepine was accomplished and their nitration, bromination, allylation, acetylatio n, formylation and oxidation reactions were studied. Nitration and bro mination of tetrahydrospiro[3H-2-benzazepine-3,1'-cycloalkane] took pl ace regioselectively on position C-8 of the phenyl ring. A nitrone was obtained for the first time in the title series. The structures of th e compounds were established by ir and nmr spectroscopy.