PROPHYLACTIC EFFECTS OF PIRENZEPINE (M(1)-BLOCKER) ON INTRAOPERATIVE STRESS-ULCER - COMPARISON WITH AN H-2-BLOCKER

Authors
TAKAKURA K HARADA J MIZOGAMI M GOTO Y
Citation
K. Takakura et al., PROPHYLACTIC EFFECTS OF PIRENZEPINE (M(1)-BLOCKER) ON INTRAOPERATIVE STRESS-ULCER - COMPARISON WITH AN H-2-BLOCKER, Anesthesia and analgesia, 78(1), 1994, pp. 84-86
Citations number
17
Categorie Soggetti
Anesthesiology
Journal title
Anesthesia and analgesia → ACNP
ISSN journal
00032999
Volume
78
Issue
1
Year of publication
1994
Pages
84 - 86
Database
ISI
SICI code
0003-2999(1994)78:1<84:PEOP(O>2.0.ZU;2-N
Abstract
Patients under general anesthesia were treated with either an H-2-bloc ker, ranitidine 50 mg, or an M(1)-blocker, pirenzepine 10 mg, and the effects of the two drugs on the gastric mucosa were compared by the me asurement of the gastric juice pH and viscosity. The results showed th at pirenzepine increased the gastric juice pH sufficiently while maint aining the gastric juice viscosity, and that ranitidine maintained the gastric juice pH higher than pirenzepine while decreasing the gastric juice viscosity. These results suggest that treatment with pirenzepin e may have advantages in the prevention of stress ulcers.