COMPARISON OF MICROSURGERY AND FIBRIN SEALANT IN REANASTOMOSIS OF THEUTERINE HORNS OF RATS

Reanastomoses of freshly divided right uterine horns of rats were perf ormed by fibrin sealant in 10 animals (group 1) and by conventional mi crosurgery in 10 animals (group 2). No surgical procedure was performe d on the left horns, which were used as controls. The tubal patency ra te in group 1 was found to be lower than that of group 2 (60% vs 90%). The mean adhesion scores of groups 1 and 2 and control were 1.7, 1.4, and 0.4, respectively. The mean scores of mucosal regeneration in gro ups 1 and 2 were 2.0 and 1.8, and the mean scores of disruption of the muscularis layer were 1.7 and 1.6, respectively. Although the scores of adhesion formation and histologic grading in group 1 were higher th an those in group 2, the differences were not significant. The ultrast ructural examination (Light and scanning electron microscope) of the r eanastomosis sites of group 1 was comparable with that of group 2. We conclude that although fibrin sealant seems to be an alternative to mi crosurgery, with comparable results, it is premature to use fibrin glu e in the human being in the light of this animal study.