Rc. Pierce et Pw. Kalivas, A CIRCUITRY MODEL OF THE EXPRESSION OF BEHAVIORAL SENSITIZATION TO AMPHETAMINE-LIKE PSYCHOSTIMULANTS, Brain research reviews, 25(2), 1997, pp. 192-216
Repeated exposure to psychostimulants such as cocaine and amphetamine
produces behavioral sensitization, which is characterized by an augmen
ted locomotor response to a subsequent psychostimulant challenge injec
tion. Experimentation focused on the neural underpinnings of behaviora
l sensitization has progressed from a singular focus on dopamine trans
mission in the nucleus accumbens and striatum to the study of cellular
and molecular mechanisms that occur throughout the neural circuitry i
n which the mesocorticolimbic dopamine projections are embedded. This
research effort has yielded a conglomerate of data that has resisted s
imple interpretations, primarily because no single neuronal effect is
likely to be responsible for the expression of behavioral sensitizatio
n. The present review examines the literature and critically evaluates
the extent to which the neural consequences of repeated psychostimula
nt administration are associated with the expression of behavioral sen
sitization. The neural alterations found to contribute to the long-ter
m expression of behavioral sensitization are centered in a collection
of interconnected limbic nuclei, which are termed the 'motive' circuit
. This neural circuit is used as a template to organize the relevant b
iochemical and molecular findings into a model of the expression of be
havioral sensitization. (C) 1997 Elsevier Science B.V.