CLINICAL-TRIAL OF MOXIDECTIN ORAL GEL IN HORSES

A clinical trial carried out over 98 days was done to evaluate treatme nt of horses with moxidectin gel for efficacy as measured by (I) reduc tion in the production of parasite ova post treatment, (2) a compariso n of the posttreatment parasite egg count suppression of moxidectin to ivermectin, and (3) assessment of the field safety, animal acceptance of the moxidectin formulation, and the utility of the moxidectin deli very device. One hundred and fifty Standardbred horses with naturally acquired parasite infections were used in the study. Moxidectin had mo re prolonged and greater suppressive influence than did ivermectin on reappearance and magnitude of strongyle egg counts post treatment, Dif ferences were not observed between the capability of ivermectin or mox idectin to reduce and suppress low Parascaris equorum egg counts. Adve rse reactions to treatments were not observed, and the utility of the moxidectin delivery syringe and animal acceptance of moxidectin treatm ent were satisfactory. (C) 1997 Elsevier Science B.V.