TUMOR-NECROSIS-FACTOR-ALPHA, INTERLEUKIN-1-BETA AND IMMUNOGLOBULIN (GM AND KM) POLYMORPHISMS IN LEPROSY - A LINKAGE STUDY

Authors
LEVEE G SCHURR E PANDEY JP
Citation
G. Levee et al., TUMOR-NECROSIS-FACTOR-ALPHA, INTERLEUKIN-1-BETA AND IMMUNOGLOBULIN (GM AND KM) POLYMORPHISMS IN LEPROSY - A LINKAGE STUDY, Experimental and clinical immunogenetics, 14(2), 1997, pp. 160-165
Citations number
21
Categorie Soggetti
Genetics & Heredity",Immunology,Biology
Journal title
Experimental and clinical immunogenetics → ACNP
ISSN journal
02549670
Volume
14
Issue
2
Year of publication
1997
Pages
160 - 165
Database
ISI
SICI code
0254-9670(1997)14:2<160:TIAI(>2.0.ZU;2-4
Abstract
In order to determine the genetic components of susceptibility to lepr osy in 6 multiplex French Polynesian families, linkage analysis was ca rried out between a putative disease gene and 6 polymorphic loci: G1M, G2M, KM, IL-1 beta TNF-alpha (1, 2) and TNF-alpha (A, G) using the lo d score method. The three modes of inheritance, assuming a full penetr ance value or reduced penetrance values (80 and 40%) for the susceptib le allele, as well as with affected ones only, were tested. The result s of this study provide no evidence for linkage between leprosy and th e markers tested.