Isothermal compressibilities, kappa(T), at 298.15 K and ambient pressu
re were obtained from published sources for more than 150 liquids of v
arious functionality, either directly or via the adiabatic compressibi
lities, kappa(s). They were related to other properties of these liqui
ds by means of a stepwise linear regression statistical program. A com
bination of the molar volume, the intrinsic volume, the isobaric expan
sibility, and the vapor pressure, with some structural features being
taken into account, was able to explain ca. 95% of the variance of the
data. This dependence was rationalized in terms of the void, compress
ible volumes in the liquids. The predictive expression was applied to
a further group of 40 common liquids, for which no values of kappa(T)
could be found.