ACROLEIN GENOTOXICITY IN DROSOPHILA-MELANOGASTER .2. INFLUENCE OF MUS201 AND MUS308 MUTATIONS

Authors
BARROS AR COMENDADOR MA SIERRA LM
Citation
Ar. Barros et al., ACROLEIN GENOTOXICITY IN DROSOPHILA-MELANOGASTER .2. INFLUENCE OF MUS201 AND MUS308 MUTATIONS, MUTATION RESEARCH, 306(1), 1994, pp. 1-8
Citations number
43
Categorie Soggetti
Genetics & Heredity",Toxicology
Journal title
MUTATION RESEARCH → ACNP
ISSN journal
00275107
Volume
306
Issue
1
Year of publication
1994
Pages
1 - 8
Database
ISI
SICI code
0027-5107(1994)306:1<1:AGID.I>2.0.ZU;2-P
Abstract
The influence of mus201 and mus308 mutants on acrolein mutagenicity wa s analyzed with the Drosophila melanogaster sex-linked recessive letha l test (SLRL), using the maternal approach, to further study the mecha nisms of action of this chemical. The hypermutability indices obtained were 2.59 for mus201 and 0.52 for mus308 conditions. Statistical anal ysis indicates that whereas part of the acrolein-induced lesions are r epaired by excision mechanism, as expected for a cyclic agent, there i s no demonstrable influence of the mus308 locus on the mutagenicity of this chemical.