Ar. Barros et al., ACROLEIN GENOTOXICITY IN DROSOPHILA-MELANOGASTER .2. INFLUENCE OF MUS201 AND MUS308 MUTATIONS, MUTATION RESEARCH, 306(1), 1994, pp. 1-8
The influence of mus201 and mus308 mutants on acrolein mutagenicity wa
s analyzed with the Drosophila melanogaster sex-linked recessive letha
l test (SLRL), using the maternal approach, to further study the mecha
nisms of action of this chemical. The hypermutability indices obtained
were 2.59 for mus201 and 0.52 for mus308 conditions. Statistical anal
ysis indicates that whereas part of the acrolein-induced lesions are r
epaired by excision mechanism, as expected for a cyclic agent, there i
s no demonstrable influence of the mus308 locus on the mutagenicity of
this chemical.