SYNTHESIS, STRUCTURES AND BIOLOGICAL-ACTIVITY OF SOME 4-AMINO-3-CINNOLINE-CARBOXYLIC ACID-DERIVATIVES .3. 1,3-OXAZINO[5,4-C]CINNOLINES AND PYRIMIDO[5,4-C]CINNOLINES

Authors
STANCZAK A PAKULSKA W
Citation
A. Stanczak et W. Pakulska, SYNTHESIS, STRUCTURES AND BIOLOGICAL-ACTIVITY OF SOME 4-AMINO-3-CINNOLINE-CARBOXYLIC ACID-DERIVATIVES .3. 1,3-OXAZINO[5,4-C]CINNOLINES AND PYRIMIDO[5,4-C]CINNOLINES, Die Pharmazie, 52(11), 1997, pp. 838-843
Citations number
17
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Die Pharmazie → ACNP
ISSN journal
00317144
Volume
52
Issue
11
Year of publication
1997
Pages
838 - 843
Database
ISI
SICI code
0031-7144(1997)52:11<838:SSABOS>2.0.ZU;2-D
Abstract
6,7,8-Substituted 4-amino-3-cinnolinecarboxylic acids 1 were condensed with acid anhydrides to corresponding 1,3-oxazino[5,4-c]cinnolines 2. The reactions of 1,3-oxazino[5,4-c]cinnolines 2 with amines, hydrazin e, hydroxylamine, alanine ethyl ester provided pyrimido[5,4-c]cinnolin es 3, 4. Selected 3-substituted 3-methylpyrimido[5,4-c]cinnolin-4(3 H) -ones have been screened for CNS activity.