COMBINATION THERAPY WITH FLUCONAZOLE AND FLUCYTOSINE FOR PULMONARY CRYPTOCOCCOSIS

We investigated, in vitro, the combined effects of fluconazole (FLCZ) and flucytosine (5-FC) against different strains of Cryptococcus neofo rmans, and retrospectively analyzed the clinical efficacy of combinati on therapy of FLCZ and 5-FC in patients with pulmonary cryptococcosis, The minimum inhibitory concentrations (MICs) of antifungal agents and drug interaction were determined by the broth microdilution method an d checkerboard titration, FLCZ and 5-FC showed synergistic activity ag ainst 8 (32%) of 25 strains of C. neoformans. The clinical efficacy of the 2 drugs when combined together was good in 9 (90%) patients and f air in 1 (10%) patient with pulmonary cryptococcosis, Renal dysfunctio n occured in 1 patient. Our results suggest that a combination therapy using FLCZ and 5-FC is clinically useful in patients with pulmonary c ryptococcosis who otherwise show a limited response to monotherapy.