BRADYCARDIA ASSOCIATED WITH INTRAVENOUS ADMINISTRATION OF TACROLIMUS IN A LIVER-TRANSPLANT RECIPIENT

Cardiotoxicity due to tacrolimus is documented infrequently in the med ical literature. Sinus bradycardia associated with intravenous tacroli mus occurred in a 15-year-old orthotopic liver transplant recipient. T he mechanism of this adverse effect is unknown; however, it does not a ppear to be concentration dependent, and in this patient it resolved o n changing to oral therapy. Practitioners should be aware that intrave nous administration of tacrolimus may be associated with adverse cardi ac events including sinus bradycardia.