Surgical decompression of the orbit may be necessary in dysthyroid pat
ients with compressive optic neuropathy, Two-wall decompression with a
trans-antral or a trans-conjunctival approach is commonly used, Howev
er, in some patients the initial improvement following this surgical p
rocedure is not maintained, Although this may be due to disease progre
ssion, a variant of orbital anatomy can contribute to sub-optimal deco
mpression, We report three cases in which recurrence of compressive op
tic neuropathy occurred following two-wall decompression, The sphenoid
al sinus was placed anteriorly in these patients, Further decompressio
n which included the lateral wall of the sphenoidal sinus resulted in
improvement. An endoscopic approach provides superior access and visib
ility for decompression of the optic nerve into the sphenoidal sinus,
and this approach may be the surgical treatment of choice in these cas
es.