A CASE-CONTROL STUDY ON RISK-FACTORS FOR LOCAL RECURRENCES OR DISTANTMETASTASES IN BREAST-CANCER PATIENTS TREATED WITH BREAST-CONSERVING SURGERY

A case-control study was conducted on 143 case-control sets recruited from the 18 key hospitals/institutes in Japan to identify risk factors for local recurrences and distant metastases after breast-conserving surgery in breast cancer patients: (1) positive surgical margin was a risk factor for local recurrences (relative risk (RR) = 16.70, p < 0.0 01) but not for distant metastases, (?) positive p53 immunostaining wa s a risk factor for both local recurrences (RR = 5.62, p = 0.003) and distant metastases (RR = 3.11, p = 0.034), (3) lymph node metastasis w as a risk factor for distant metastases (RR = 9.28, p = 0.001) but not for local recurrences, (4) radiation therapy reduced local recurrence s (RR = 0.13, p = 0.004) and (5) adjuvant chemotherapy (RR = 0.27, p = 0.120), endocrine therapy (RR = 0.21, p = 0.037), and chemoendocrine therapy (RR = 0.05, p = 0.013) reduced local recurrences.