STRUCTURE OF A NOVEL ANTIMALARIAL GALLIUM(III) COMPLEX WITH SELECTIVEACTIVITY AGAINST CHLOROQUINE-RESISTANT PLASMODIUM-FALCIPARUM

Authors
SHARMA V BEATTY A GOLDBERG DE PIWNICAWORMS D
Citation
V. Sharma et al., STRUCTURE OF A NOVEL ANTIMALARIAL GALLIUM(III) COMPLEX WITH SELECTIVEACTIVITY AGAINST CHLOROQUINE-RESISTANT PLASMODIUM-FALCIPARUM, Chemical communications, (22), 1997, pp. 2223-2224
Citations number
22
Categorie Soggetti
Chemistry
Journal title
Chemical communications → ACNP
ISSN journal
13597345
Issue
22
Year of publication
1997
Pages
2223 - 2224
Database
ISI
SICI code
1359-7345(1997):22<2223:SOANAG>2.0.ZU;2-U
Abstract
The crystal structure of an amine:phenol complex of gallium(III), [(1, 12-bis(2-hydroxy-3-methoxybenzyl)-1,5,8, 12-tetraazadodecane} gallium( III)I [Ga(madd)](+), a potent new antimalarial which selectively targe ts chloroquine-resistant organisms is reported; the compound is shown to directly inhibit heme polymerization.