HYPERINSULINEMIA IN PATIENTS WITH SPASTIC ANGINA-PECTORIS

We evaluated the association between coronary spasm and hyperinsulinem ia (high immunoreactive insulin, IRI) in patients with angina pectoris . The study cohort comprised 30 patients with spastic angina pectoris, 30 patients with angina pectoris showing fixed-obstructive coronary s clerosis and 30 control subjects who were matched for body mass index, age and sex. A 75-gram oral glucose test was performed, and blood sug ar and IRI were serially measured concomitant with serum total cholest erol, triglyceride and HDL cholesterol. The IRI level at 60 min, the p eak IRI during the test, Sigma IRI and Sigma IRI/Sigma blood sugar wer e significantly higher in the patients than in the controls. Total cho lesterol and LDL cholesterol levels were significantly increased in pa tients showing fixed-obstructive coronary sclerosis compared to contro ls.