OPTICALLY-ACTIVE PROPARGYLIC AND ALLYLIC ALCOHOLS WITH A DIFLUOROMETHYL GROUP AT THE TERMINAL CARBON

Authors
XIAO L KITAZUME T
Citation
L. Xiao et T. Kitazume, OPTICALLY-ACTIVE PROPARGYLIC AND ALLYLIC ALCOHOLS WITH A DIFLUOROMETHYL GROUP AT THE TERMINAL CARBON, Tetrahedron : asymmetry, 8(21), 1997, pp. 3597-3601
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
8
Issue
21
Year of publication
1997
Pages
3597 - 3601
Database
ISI
SICI code
0957-4166(1997)8:21<3597:OPAAAW>2.0.ZU;2-L
Abstract
Enantioselective esterification of oc-substituted propargylic alcohols was found to proceed very smoothly in the presence of a catalytic amo unt of lipase (Nobozym 435) to yield the corresponding (R)-alcohols an d (S)-acetates with high enantiomeric excess. Further, the preparation of optically active propargylic and allylic alcohols with a difluorom ethyl group at the terminal carbon is described. (C) 1997 Elsevier Sci ence Ltd.