A SHORT AND EFFICIENT ENANTIOSELECTIVE SYNTHESIS OF CYCLOHEXYLNORSTATINE, A KEY COMPONENT OF A RENIN INHIBITOR

Authors
UPADHYA TT SUDALAI A
Citation
Tt. Upadhya et A. Sudalai, A SHORT AND EFFICIENT ENANTIOSELECTIVE SYNTHESIS OF CYCLOHEXYLNORSTATINE, A KEY COMPONENT OF A RENIN INHIBITOR, Tetrahedron : asymmetry, 8(21), 1997, pp. 3685-3689
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
8
Issue
21
Year of publication
1997
Pages
3685 - 3689
Database
ISI
SICI code
0957-4166(1997)8:21<3685:ASAEES>2.0.ZU;2-Q
Abstract
A catalytic asymmetric synthesis of ethyl (2R, nesulfonyl)-3-amino-4-c yclohexyl-2-hydroxybutyrate 7 in 96% ee from cheaply available cyclohe xanone is described employing Sharpless asymmetric aminohydroxylation as the key step. (C) 1997 Elsevier Science Ltd.