PERMUTATIONAL ORGANIC-SYNTHESIS IN ADDRESSABLE MICROREACTORS (POSAM(TM)) - AN EFFICIENT, INEXPENSIVE AND VERSATILE SOLID-PHASE PROTOCOL FORTHE PREPARATION OF LIBRARIES OF COMPOUNDS ON THE 0.01 TO 1.0 MILLIMOLE (OR LARGER) SCALE

Authors
GANI D AKHTAR M KROLL FEK SMITH CFM STONES D
Citation
D. Gani et al., PERMUTATIONAL ORGANIC-SYNTHESIS IN ADDRESSABLE MICROREACTORS (POSAM(TM)) - AN EFFICIENT, INEXPENSIVE AND VERSATILE SOLID-PHASE PROTOCOL FORTHE PREPARATION OF LIBRARIES OF COMPOUNDS ON THE 0.01 TO 1.0 MILLIMOLE (OR LARGER) SCALE, Tetrahedron letters, 38(49), 1997, pp. 8577-8580
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
49
Year of publication
1997
Pages
8577 - 8580
Database
ISI
SICI code
0040-4039(1997)38:49<8577:POIAM(>2.0.ZU;2-Z
Abstract
Apparatus for the solid-phase synthesis of libraries of 10 milligramme quantities of compounds consisting of machined frit glass microreacto rs and precision engineered jacketed microreactor vessel tubes, is des cribed. The apparatus provides an inert environment for reactions requ iring some of the most basic and acidic conditions used in conventiona l organic synthesis over the temperature range -80 to 200 degrees C an d is suitable for the synthesis of libraries of upto 600 members. (C) 1997 Elsevier Science Ltd.