SOLID-PHASE SYNTHESIS OF DIVERSE TETRAHYDRO-1,4-BENZODIAZEPINE-2-ONES

Authors
BHALAY G BLANEY P PALMER VH BAXTER AD
Citation
G. Bhalay et al., SOLID-PHASE SYNTHESIS OF DIVERSE TETRAHYDRO-1,4-BENZODIAZEPINE-2-ONES, Tetrahedron letters, 38(48), 1997, pp. 8375-8378
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
48
Year of publication
1997
Pages
8375 - 8378
Database
ISI
SICI code
0040-4039(1997)38:48<8375:SSODT>2.0.ZU;2-8
Abstract
A general method for the construction of tetrahydro-1,4-benzodiazepine -2-ones on solid-support has been developed utilising a cleavage-conju gate addition protocol as the key step in the design. Using this novel methodology the synthesis of a diverse one hundred and twenty compoun d library with three points of diversity has been achieved starting fr om readily available anthranilic esters. (C) 1997 Elsevier Science Ltd .