A VASCULAR SMOOTH MUSCLES NITRIC-OXIDE RELAXATION BY A MECHANISM DISTINCT OF CALCIUM CHANGES

Authors
CHABAUD F DANNA M BENY JL
Citation
F. Chabaud et al., A VASCULAR SMOOTH MUSCLES NITRIC-OXIDE RELAXATION BY A MECHANISM DISTINCT OF CALCIUM CHANGES, Life sciences, 54(19), 1994, pp. 1449-1458
Citations number
30
Categorie Soggetti
Biology,"Medicine, Research & Experimental","Pharmacology & Pharmacy
Journal title
Life sciences → ACNP
ISSN journal
00243205
Volume
54
Issue
19
Year of publication
1994
Pages
1449 - 1458
Database
ISI
SICI code
0024-3205(1994)54:19<1449:AVSMNR>2.0.ZU;2-F
Abstract
Prostaglandin F2alpha contracts coronary arteries smooth muscles under conditions of extra cellular and intracellular calcium depletion. In these conditions, nitrogen-oxide-containing vasodilators or natural ED RF(s) released by the kinins, substance P and bradykinin, from the end othelium relax strips of pig coronary arteries. This indicates that ni tric oxide not only needs to lower cytosolic free calcium to relaxes t he smooth muscles, but in addition another mechanism, independent of c ytosolic calcium changes, is necessary to fully relax strips contracte d by Prostaglandin F2alpha.