STUDY ON THE ABSORPTION OF VINPOCETINE AND APOVINCAMINIC ACID

The absorption of vinpocetine (Cavinton) and apovincaminic acid, compo unds showing a marked difference in their physico-chemical properties, was studied in rats in in situ loop experiments by using radiolabelle d compounds. In the case of apovincaminic acid, the investigations als o involved the estimation of the portion of radioactivity excreted in urine and faeces after i.v. and p.o. administration of the compound. A ccording to our results, it can be concluded that both vinpocetine and apovincaminic acid are absorbed from the gastrointestinal tract - apo vincaminic acid mainly from the stomach, while vinpocetine is absorbed from the small intestine.