EFFECT MODELING FOR DRUGS UNDERGOING ENTEROHEPATIC CIRCULATION

Authors
HOGLUND P OHLIN M
Citation
P. Hoglund et M. Ohlin, EFFECT MODELING FOR DRUGS UNDERGOING ENTEROHEPATIC CIRCULATION, European journal of drug metabolism and pharmacokinetics, 18(4), 1993, pp. 333-338
Citations number
13
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of drug metabolism and pharmacokinetics → ACNP
ISSN journal
03787966
Volume
18
Issue
4
Year of publication
1993
Pages
333 - 338
Database
ISI
SICI code
0378-7966(1993)18:4<333:EMFDUE>2.0.ZU;2-M
Abstract
A multi-compartment pharmacokinetic model with enterohepatic circulati on, was used in simulations and in a clinical trial with morphine. A h ypothetical effect compartment was linked to either the central Or the PeriPheral disposition compartment.