ALLOGENEIC BONE-MARROW TRANSPLANTATION FOR AL AMYLOIDOSIS

AL amyloidosis is an infiltrative disorder characterized by the extrac ellular deposition of insoluble fibrillar immunoglobulin light chains whose production results from a plasma cell dyscrasia. Treatment with melphalan has resulted in an improvement in a few patients. Recently, intensive chemotherapy followed by autologous or syngeneic stem cell s upport has been shown to offer potential benefit. Allogeneic stem cell support after intensive therapy would retain the benefits of autologo us transplantation, with the additional advantages of a tumor-free gra ft and of a possible graft-versus-tumor effect. We report a patient wi th AL amyloidosis and significant proteinuria, She improved after an a llogeneic bone marrow transplantation.