QUINOLONE ARTHROPATHY IN ANIMALS VERSUS CHILDREN

The use of quinolones in children and accumulation of data on the phar macodynamics of these drugs have been limited and delayed by concern r egarding their chondrotoxicity. A comprehensive review of the findings in animals compared with the cumulative published findings in childre n and adolescents (>7,000 to date) allows the conclusion that such con cern is not justified. Prospective controlled studies in children are justifiable in view of a continuing lack of correlation between findin gs in juvenile animals and those in children and because of the select ed therapeutic advantages of the current and newer quinolones.