ACREMONIUM SPECIES - NEW EMERGING FUNGAL OPPORTUNISTS - IN-VITRO ANTIFUNGAL SUSCEPTIBILITIES AND REVIEW

We provide an overview of opportunistic fungal infections caused by Ac remonium (Cephalosporium) species and discuss the classification of th ese species as well as the diagnosis and treatment of acremonium infec tions, We used a microdilution broth method to compare in vitro suscep tibilities and minimum inhibitory concentrations and minimum fungicida l concentrations of amphotericin B, miconazole, itraconazole, 5-fluoro cytosine, fluconazole, and ketoconazole for 33 clinical and environmen tal isolates of Acremonium. In general, the isolates tested displayed little susceptibility to the antifungals tested. Fluconazole and 5-flu orocytosine were ineffective in all cases. The efficacy of the remaini ng drugs was dependent on the strain, Amphotericin B showed the best r esults.