TRANSFER OF ELEVATED ANTI-S-100 AUTOIMMUNITY FROM MOTHER TO OFFSPRINGIN RATS

Pregnant Wistar female rats were injected with polyclonal rabbit antib odies (AB) to S-100 brain protein. Control groups received equivalent amount of AB to bovine serum albumin or non-immune rabbit's IgG. An in creased level of anti-S100 immunoreactivity was detected by ELISA or i ts enhanced variant ASPAG (from Amplified Solid Phase Attached Antigen -Antibody Grid formation) in the serum of 1 month old offsprings of gr oup treated with AB to S-100. Obtained data indicate the possibility o f inborn epigenetical ''imprinting'' of specific autoimmune reactions which may be important for the development of certain forms of nervous system diseases.