ISAACS-SYNDROME - LONG-TERM IMPROVEMENT A FTER INTRAVENOUS POLYVALENTIMMUNOGLOBULINS

A 35 year-old man developed a syndrome with muscle cramp, myokimia, ge neralized, fasciculations, excessive sweating, sleep disorders and sev ere impairment it was a syndrome of continuous muscle fiber activity - or Isaacs syndrome-with central disorders (this may be called ''Malad ie de Morvan''). Previous reports have suggested that Isaac's syndrome might be an autoimmune disorder. Moreover high doses intravenous immu noglobulins were given resulting in a substantal improvement six month s alter the onset of the treatment.