PERCUTANEOUS ETHANOL INJECTION IN THE TREATMENT OF HEPATOCELLULAR-CARCINOMA - A MULTICENTER SURVEY OF EVALUATION PRACTICES AND COMPLICATIONRATES

Background: Percutaneous ethanol injection (PEI) has become a widely u sed procedure in the treatment of hepatocellular carcinoma (HCC). Howe ver, the criteria for selecting patients are not standardized, and lit tle information is available about the complications of the procedure. Methods: A questionnaire was sent to 11 experienced Italian centers. It investigated: the size and the number of HCC nodules suitable for t reatment and the Child-Pugh risk class of the associated cirrhosis; th e performance of the procedure; the number and characteristics of the patients treated; and, finally, any complications. Results: Most of th e centers performed PEI in single HCC nodules less than 5 cm in diamet er or in multiple nodules if fewer than three, the larger being less t han 3 cm. Patients in Child-Pugh's classes A, B, and C with single nod ules were generally considered for PEI. A prothrombin time of less tha n 40% and a platelet count of less than 40,000/mm(3) contraindicated P EI in most of the centers. PEI was generally performed on outpatients, using Chiba or spinal needles. One thousand and sixty-six patients (8 118 sessions) were enrolled; 74% had a single HCC nodule and 26% multi ple nodules. All except four had cirrhosis; 53% were in Child class A, 38% in class B, and 9% in class C. The mean number of sessions needed to destroy an HCC nodule was 6.7 (range, 2-14), with a mean alcohol i njection volume of 5.0 ml per session (range, 2-20 ml). One death (0.0 9%) and 34 complications (3.2%) were reported. Among the complications we call attention to the hemorrhagic ones (eight cases) and tumoral s eeding (seven cases). Severe pain experienced during the maneuver led to discontinuation of the procedure in 3.7% of the patients; 13.5% of the patients required analgesics and 24% had fever after PEI. Conclusi ons: Some procedural aspects of PEI treatment differ among the various centers: a standardization is advisable. In the present survey PEI is a low-risk technique.