This review starts from the classical standpoint that there are at lea
st two separable processes acting with respect to axis formation and t
issue specification in the early Xenopus embryo: a UV-insensitive even
t establishing a postgastrula embryo consisting of three concentric ge
rm layers, ectoderm, mesoderm and endoderm, all of a ventral character
; and a UV-sensitive event producing tissue of a dorsal type, includin
g somites, notochord and neural tissue, and concomitantly establishing
the dorsoventral and anteroposterior axes. The experimental evidence
suggesting the molecular basis of the dorsal and ventral pathways is r
eviewed.