CLEAR-CELL TUMORS OF THE FEMALE GENITAL-TRACT

Clear cell adenocarcinomas of the vagina, cervix, endometrium, and ova ries show very similar histological features. Several other tumors and tumor-like lesions of the female genital tract may also contain clear cells and may occasionally be misinterpreted as clear cell adenocarci nomas. These conditions include microglandular hyperplasia, mesonephri c hyperplasia, Arias-Stella change, smooth muscle tumors containing cl ear cells, dysgerminoma, yolk sac tumor, metastatic renal cell carcino ma, steroid cell tumors, hepatoid carcinomas, signet-ring-cell stromal tumors, and trophoblastic tumors. This review discusses the histologi cal features of all of these lesions, emphasizing the morphological as pects that are essential to accurate differential diagnosis. Copyright (C) 1997 by W.B. Saunders Company.