VASCULAR ENDOTHELIAL GROWTH-FACTOR VASCULAR-PERMEABILITY FACTOR IS DETECTABLE IN THE SERA OF TUMOR-BEARING MICE AND CANCER-PATIENTS

Authors
KONDO S ASANO M MATSUO K OHMORI I SUZUKI H
Citation
S. Kondo et al., VASCULAR ENDOTHELIAL GROWTH-FACTOR VASCULAR-PERMEABILITY FACTOR IS DETECTABLE IN THE SERA OF TUMOR-BEARING MICE AND CANCER-PATIENTS, Biochimica et biophysica acta. Molecular cell research, 1221(2), 1994, pp. 211-214
Citations number
21
Categorie Soggetti
Biology,Biophysics
Journal title
Biochimica et biophysica acta. Molecular cell research → ACNP
ISSN journal
01674889
Volume
1221
Issue
2
Year of publication
1994
Pages
211 - 214
Database
ISI
SICI code
0167-4889(1994)1221:2<211:VEGVFI>2.0.ZU;2-W
Abstract
We developed an enzyme-linked immunosorbent assay (ELISA) for vascular endothelial growth factor/vascular permeability factor (VEGF/VPF). Th e assay revealed that VEGF/VPF levels in the sera of mice were signifi cantly increased from undetectable level by s.c. transplantation with a solid tumor. We also measured VEGF/VPF levels in serum specimens obt ained from cancer patients with several types of cancers. VEGF/VPF lev els in the sera from cancer patients were significantly higher than th ose in the sera from the individuals with no sign of cancer.