FOLINIC ACID AND ENHANCED RENAL ELIMINATION IN FORMIC-ACID INTOXICATION

Ingestion of over 60 g of formic acid by an adult is potentially fatal . We report a case of a 36-year-old woman with a history of depression who ingested 110 g of formic acid. She survived a complicated intensi ve care hospitalization following usage of intravenous folinic acid, u rinary alkalinization, intravenous furosemide and supportive care. We suggest a management protocol aimed at minimizing formate toxicity by enhancing hepatic formate degradation via the folinic acid 'one carbon pool' and by enhanced renal elimination of formate.