Herpes simplex virus infection in immunocompromised individuals, inclu
ding AIDS patients, is characterized by its tendency for atypical pres
entations and unusual locations, often resulting in delayed diagnosis
and treatment. Three HIV-infected patients who developed prolonged cut
aneous lesions of the fingers are presented, These lesions were unmodi
fied by previous antibiotic treatment, and rapidly progressed to the c
omplete destruction of nail structures in two patients, Viral culture
confirmed the diagnosis of herpetic whitlow in all cases, and treatmen
t with oral aciclovir resulted in complete recovery Surgical treatment
was not necessary.