RECENT PROGRESS IN DETECTION-ORIENTED DER IVATIZATION

Derivatization reactions to enhance the sensitivity and selectivity of gas and high-performance liquid chromatographic detection of biologic ally important substances are reviewed, with emphasis on the papers re ported in the last decade. The achiral and chiral reagents for various functional groups, such as amino, carboxy, thiol, carbonyl and hydrox y groups, include phthalimidyl, quinolyl, quinoxalyl, benzoxazolyl and benzoxadiazolyl analogous having a reacting group to make a covalent bond with analytes. The derivatization methods for increasing sensitiv ity in liquid chromatography combined with mass spectrometry are also discussed.