HAMIGERONE AND DIHYDROHAMIGERONE - 2 ACETATE-DERIVED, ANTIFUNGAL METABOLITES FROM HAMIGERA-AVELLANEA

Authors
BREINHOLT J KJOER A OLSEN CE RASSING BR ROSENDAHL CN
Citation
J. Breinholt et al., HAMIGERONE AND DIHYDROHAMIGERONE - 2 ACETATE-DERIVED, ANTIFUNGAL METABOLITES FROM HAMIGERA-AVELLANEA, Acta chemica Scandinavica, 51(12), 1997, pp. 1241-1244
Citations number
3
Categorie Soggetti
Chemistry,Biology
Journal title
Acta chemica Scandinavica → ACNP
ISSN journal
0904213X
Volume
51
Issue
12
Year of publication
1997
Pages
1241 - 1244
Database
ISI
SICI code
0904-213X(1997)51:12<1241:HAD-2A>2.0.ZU;2-9
Abstract
The fungus Hamigera avellanea is found to be the source of two metabol ites, hamigerone (C25H32O5) and dihydrohamigerone (C25H34O5), the form er exhibiting in vitro growth inhibitory activity against phytopathoge nic fungi. Their chemical structures and configurations, save for deta ils related to the stereochemistry, have been established by a variety of spectroscopic techniques. Feeding the fungus with specifically lab elled C-13-precursors served to establish the biosynthetic derivation of the two metabolites from ten intact acetate and five methionine-der ived C-1-units.