PRIMARY ADENOSQUAMOUS CARCINOMA OF LIVER RESECTED BY RIGHT TRISEGMENTECTOMY - REPORT OF A CASE AND REVIEW OF THE LITERATURE

A case of primary adenosquamous carcinoma of the liver in a patient wi th an elevated level of serum squamous cell carcinoma-related antigen is reported. A 68-year-old man was admitted to our hospital with a 10- day history of fever and jaundice. From the results of laboratory and imaging studies before surgery, a diagnosis of cholangiocellular carci noma was made, and the patient underwent right trisegmentectomy with r egional cr lymph node dissection. Histopathological examination of the resected specimen revealed adenocarcinoma, squamous cell carcinoma, a nd a transitional area containing both types of cancer cells. The numb er of argyrophilic nucleolar organizer regions and the labeling index of proliferating cell nuclear antigen were markedly elevated and the d eoxyribonucleic acid ploidy pattern was aneuploid in the squamous comp onent. The patient died due to liver metastases 3 months after the ope ration. We reviewed the 31 cases of adenosquamous carcinoma of the liv er reported in the Japanese and English language literature,including the present case.