THE EFFECT OF HEPARINIZATION ON INTRAABDOMINAL INFECTION AND ACUTE PULMONARY FAILURE

Acute severe purulent peritonitis is still a very life-threatening dis ease condition. The primary cause of death is multiple organ failure ( MOF) where acute respiratory distress syndrome (ARDS) is the initial t rigger, Studies have shown that heparin has a cytoprotective effect an d stimulates an increase in cardiopulmonary function systematically. M ethods. Twenty-one Sprauge Dawley rats were used as an animal model by puncturing the distal wall of intestine and ligating the appendix wit hout interfering with the continuity of intestinal tract, In the forma l experiments, 100 rats were divided into two groups and equal amounts of distilled water was given intraperitoneally, Total mortality and e arly mortality rate were recorded, Abdominal autopsies and blood gas a nalyses were performed and lung tissue samples were taken for light an d electronic microscope analyses. Results. The mortality rate was not statistically significant, But early death rate, the average survival times and the rate of abscess formation were significantly lower in th e heparin treated group, The histological study of the experimental sp ecimen showed that in the control group, the incidence of ARDS was hig her and there was a more severe ARDS-like change, especially polymorph onuclear neutrophil leukocytes infiltration into alveolar and intersti tial spaces, Blood gas analysis demonstrated the beneficial aspects of heparin administration. Conclusions. Heparin can increase the early s urvival rate and increase the survival time of rats with experimental acute severe purulent peritonitis, and proves to be beneficial in prev enting infection induced lung injury during sepsis, We conclude that t he effect of heparin on the survival rate is related to less pulmonary function deterioration, thereby preventing ARDS and the triggering of MOF.